Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

S Wen, KL Carey, Y Nakao, N Fusetani…

Index: Organic Letters, , vol. 9, # 6 p. 1105 - 1108

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Citation Number: 40

Abstract

... Volume: Page: ... Organic Letters. ... In practice, benzyl 4-pentynoate was subjected to Martín's four-step sequence 9 for conversion of an acetylene to a β,γ-cis-unsaturated aldehyde (Scheme 1). The fragile aldehyde 7a was successfully converted to sulfinylimine 8a ...

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