Design, synthesis and investigation on the structure–activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents

…, B Wan, S Cho, SG Franzblau, G Costantino

Index: Pieroni, Marco; Wan, Baojie; Cho, Sanghyun; Franzblau, Scott G.; Costantino, Gabriele European Journal of Medicinal Chemistry, 2014 , vol. 72, p. 26 - 34

Full Text: HTML

Citation Number: 20

Abstract

Abstract Tuberculosis (TB) is one of the deadliest infectious diseases of all times, and its recent resurgence is a supreme matter of concern. Co-infection with HIV and, in particular, the continuous isolation of new resistant strains, makes the discovery of novel anti-TB agents a strategic priority. The research of novel agents should be driven by the accessibility of the synthetic procedure and, in particular, by the lack of cross-resistance with the drugs ...