A Simple, Efficient and Solvent-Free Protocol for the Friedlaender Synthesis of Quinolines by Using SnCl2 2H2O

P Arumugam, G Karthikeyan, R Atchudan…

Index: Arumugam, Pandurangan; Karthikeyan, Ganesan; Atchudan, Raji; Muralidharan; Perumal, Paramasivan T. Chemistry Letters, 2005 , vol. 34, # 3 p. 314 - 315

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Citation Number: 56

Abstract

Quinoline and its derivatives display a wide spectrum of bi- ological activities such as antimalarial, antibacterial, antidiabet- ic, and anti-inflammatory1,2 behaviour. Furthermore cytotoxic agents like benzo[5,6]pyrrolizino[1,2-b]quinolines,3 antitumor agents like camptothecin4 also contain the quinoline nuclei. The benzo[5,6]pyrrolizino[1,2-b]quinoline system which dis- plays potent in vitro cytotoxic activity against MCF7 cell is syn- thesized using the Friedländer ...