Effects of oligofluorine substitution on the mutagenicity of quinoline: a study with twelve fluoroquinoline derivatives

T Kato, K Saeki, Y Kawazoe, A Hakura

Index: Kato, Taka-Aki; Saeki, Ken-Ichi; Kawazoe, Yutaka; Hakura, Atsushi Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 1999 , vol. 439, # 2 p. 149 - 157

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Citation Number: 22

Abstract

A total of 12 variously fluorinated derivatives of quinoline (Q) were tested for their mutagenicity in Salmonella typhimurium TA100 in the presence of S9 mix to investigate the structure–mutagenicity relationship in oligofluorinated quinolines. Nine of them, 3, 7-di-, 5, 6- di-, 6, 7-di-, 6, 8-di-, 7, 8-di-, 3, 5, 7-tri-, 5, 6, 8-tri-, 6, 7, 8-tri-, and 5, 6, 7, 8- tetrafluoroquinolines (FQs), were newly synthesized for this purpose. Those fluorinated at ...