… a short synthesis of melatoninCatalytic conversions in water, part 18.(Part 17: GJ ten Brink, IWCE Arends and RA Sheldon, Science, 2000, 287, 1636.) Experimental …

…, FA Sheldon, MAPJ Hacking, RA Sheldon

Index: Verspui, Goeran; Elbertse, Guido; Sheldon, Frank A.; Hacking, Michiel A. P. J.; Sheldon, Roger A. Chemical Communications, 2000 , # 15 p. 1363 - 1364

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Citation Number: 28

Abstract

Water increases the selectivity in the Rh–phosphine catalysed hydroformylation of N- allylacetamide; an aqueous–organic biphasic system, containing a hydrophobic Rh-catalyst, provided facile catalyst/product separation, after which the aqueous product phase could be used in a one-pot synthesis of N-acetyl-5-methoxytryptamine (melatonin).