Molecules

Solventless lactam synthesis by intramolecular cyclizations of α-iminoester derivatives under microwave irradiation

FZ Zradni, J Hamelin, A Derdour

Index: Zradni, Fatima-Zohra; Hamelin, Jack; Derdour, Aicha Molecules, 2007 , vol. 12, # 3 p. 439 - 454

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Citation Number: 7

Abstract

Abstract: We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five-and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both ...

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