Tetrahedron Letters

Gold-catalyzed intramolecular hydroarylation of olefins. Scope evaluation and preliminary mechanistic studies

M Jean, P Van de Weghe

Index: Jean, Mickael; Van De Weghe, Pierre Tetrahedron Letters, 2011 , vol. 52, # 27 p. 3509 - 3513

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Citation Number: 17

Abstract

Abstract We report a gold-catalyzed intramolecular hydroarylation of unactivated olefins using a combination of AuCl 3/AgOTf as the catalytic system affording dihydrobenzopyrans, tetralins and tetrahydroquinolines in good yields. For our preliminary mechanistic studies, we have investigated the kinetic isotope effects with deuterated arene compounds and found that this catalytic hydroarylation is consistent with an electrophilic aromatic ...

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