Journal of the American Chemical Society

A direct catalytic enantioselective aldol reaction via a novel catalyst design

BM Trost, H Ito

Index: Trost; Ito Journal of the American Chemical Society, 2000 , vol. 122, # 48 p. 12003 - 12004

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Citation Number: 432

Abstract

Few chemical reactions have reached the promise of the aldol reaction in its importance in the synthesis of complex molecules. 1 Almost all of the reactions are performed by preformation of an enolate, enol, or an equivalent with one of the most important versions being the Mukaiyama aldol reaction involving enol silyl ethers. In these cases, stoichiometric amounts of base and/or adjunct reagents (such as silylating agents to form the enol silyl ...

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