Quinolinoneacetic acid derivatives as novel glutathione S-transferase P1-1 inhibitors: insights into the interaction modes by molecular modeling

…, SJ Wang, DD Song, YK Jing, MS Cheng

Index: Wang, Jian; Wang, Shao-Jie; Song, Dan-Dan; Jing, Yong-Kui; Cheng, Mao-Sheng Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 2823 - 2826

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Abstract

Abstract Glutathione S-transferase P1-1 (GSTP1-1, EC 2.5. 1.18) is generally conceived to be an important player in the acquired resistance of tumor to anticancer agents, thus a series of quinolinoneacetic acid derivatives were synthesized and their inhibitory effects on GSTP- 1 were tested in this study. Interestingly, it was found that some compounds showed remarkable inhibitory effect on GSTP-1 activity. Furthermore, molecular docking study was ...