Monitoring mechanistic details in the synthesis of pyrimidines via real-time, ultrafast multidimensional NMR spectroscopy

ZD Pardo, GL Olsen, ME Fernández-Valle…

Index: Pardo, Zulay D.; Olsen, Gregory L.; Fernandez-Valle, Maria Encarnacion; Frydman, Lucio; Martinez-Alvarez, Roberto; Herrera, Antonio Journal of the American Chemical Society, 2012 , vol. 134, # 5 p. 2706 - 2715

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Citation Number: 35

Abstract

Recent years have witnessed unprecedented advances in the development of fast multidimensional NMR acquisition techniques. This progress could open valuable new opportunities for the elucidation of chemical and biochemical processes. This study demonstrates one such capability, with the first real-time Two-dimensional (2D) dynamic analysis of a complex organic reaction relying on unlabeled substrates. Implementing ...

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