An Efficient and Large Scale Process for Synthesis of Valacyclovir¶

…, R Vedantham, MD Khunt, VT Mathad…

Index: Prasada Raju; Vedantham, Ravindra; Khunt, Mayur D.; Mathad, Vijayavitthal T.; Dubey, Pramod K.; Chakravarthy, Akula Kalyan Asian Journal of Chemistry, 2010 , vol. 22, # 5 p. 4092 - 4098

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Abstract

Valacyclovir1,2, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl-L-valinate (1) is an antiviral drug used in the management of viral infections such as herpes simplex and varicella-zoster in humans. It is a prodrug, an esterifed version of acyclovir and having enhanced bioavailability (ca. 55 %) when compared to acyclovir (10-20 %) and is marketed by Glaxo Smith Kline under the trade name Valtrex3 or Saltier. Valacyclovir is a high dosage drug with a ...