Tetrahedron

Synthesis of highly functionalized phenylalanine derivatives via cross-enyne metathesis reactions

S Kotha, S Halder, E Brahmachary

Index: Kotha, Sambasivarao; Halder, Somnath; Brahmachary, Enugurthi Tetrahedron, 2002 , vol. 58, # 45 p. 9203 - 9208

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Citation Number: 41

Abstract

A new method for the synthesis of constrained phenylalanine derivatives is described. In this regard, the simple synthesis of acyclic diene building blocks embodying an α-amino acid moiety has been achieved. The diene building blocks have been prepared by cross enyne- metathesis reaction as a key step. The Diels–Alder reaction of the dienes with a dienophile such as dimethyl acetylenedicarboxilate (DMAD) followed by oxidation of the resulting ...