Tetrahedron letters

Remarkable three-step-one-pot solution phase preparation of novel imidazolines utilizing a UDC (Ugi/de-Boc/cyclize) strategy

C Hulme, L Ma, J Romano, M Morrissette

Index: Hulme, Christopher; Ma, Liang; Romano, Joseph; Morrissette, Matthew Tetrahedron Letters, 1999 , vol. 40, # 45 p. 7925 - 7928

Full Text: HTML

Citation Number: 55

Abstract

This communication reveals the novel solution phase synthesis of an array of biologically relevant imidazolines in a remarkable 'three-step-one-pot'procedure, utilizing a Ugi/de- Boc/cyclization (UDC) strategy. Transformations are carried out in excellent yield by condensation of N-Boc-α-amino-aldehydes and supporting Ugi reagents. The described protocol represents a highly attractive solution phase procedure for the rapid generation of ...

Related Articles:

A reasonably stereospecific multistep conversion of Boc-protected α-amino acids to Phth-protected β 3-amino acids

[Temperini, Andrea; Capperucci, Antonella; Degl'Innocenti, Alessandro; Terlizzi, Raffaella; Tiecco, Marcello Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4121 - 4124]

A reasonably stereospecific multistep conversion of Boc-protected α-amino acids to Phth-protected β 3-amino acids

[Temperini, Andrea; Capperucci, Antonella; Degl'Innocenti, Alessandro; Terlizzi, Raffaella; Tiecco, Marcello Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4121 - 4124]

More Articles...