Chemistry of heterocyclic compounds

4-hydroxy-2-quinolones. 149*. Synthesis, chemical transformations, and biological properties of β-N-acylhydrazides of 1-R-4-hydroxy-2-oxo-1, 2-dihydro-quinoline-4- …

IV Ukrainets, AA Tkach, LY Yang

Index: Ukrainets; Tkach; Yang, Liu Yang Chemistry of Heterocyclic Compounds, 2008 , vol. 44, # 11 p. 1347 - 1354

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Citation Number: 5

Abstract

Two methods of preparation have been proposed and the synthesis has been effected of a large series of β-N-acylhydrazides of 1-R-4-hydroxy-2-oxo-1, 2-dihydroquinoline-3- carboxylic acids. The possibility of using various condensing agents for converting them into the corresponding 1, 3, 4-oxa-diazoloquinolines has been studied. Results are given of an investigation of the antitubercular activity of the synthesized compounds.

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