Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens
…, JP Yardley, MA Abou-Gharbia, CR Lyttle…
Index: Miller; Collini; Tran; Harris; Kharode; Marzolf; Moran; Henderson; Bender; Unwalla; Greenberger; Yardley; Abou-Gharbia; Lyttle; Komm Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1654 - 1657
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Citation Number: 124
Abstract
Introduction. The onset of menopause has been associated with a reduction in endogenous estrogen levels that has been correlated with a variety of menopausal symptoms and an increased risk for osteoporosis and heart disease. 1 Hormone replacement therapy successfully alleviates these symptoms, but concerns about hyperplastic estrogen action on breast and uterine tissue have been raised. 2, 3 While the hyperplastic action of estrogen ...
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