Synthesis and chemistry of 7-amino-4-(trifluoromethyl) coumarin and its amino acid and peptide derivatives

ER Bissell, AR Mitchell, RE Smith

Index: Bissell, Eugene R.; Mitchell, Alexander R.; Smith, Robert E. Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2283 - 2287

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Citation Number: 83

Abstract

The synthesis and purification of 7-amino-4-(trifluoromethyl) courmarin, a novel fluorescent marker for the sensitive detection of proteinases, were investigated. Two byproducts, 7- hydroxy-4-(trifluoromethyl-2-quinolone and 2-ethoxy-7-hydroxy-4-(trifluoromethyl) quinoline, were isolated and identified. 7-Methoxy-4-(trifluoromethyl)-Zquinolone was also prepared. Amino acid and peptide derivatives prepared by solution methods using the stepwise ...