New bronchodilators. 3. Imidazo [4, 5-c][1, 8] naphthyridin-4 (5H)-ones

…, T Kawakita, H Manabe, S Kitamura…

Index: Suzuki, Fumio; Kuroda, Takeshi; Kawakita, Takashi; Manabe, Haruhiko; Kitamura, Shigeto; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4866 - 4874

Full Text: HTML

Citation Number: 36

Abstract

In order to develop new oral bronchodilators, a series of novel imidazo [4, 5-c][1, 8] naphthyridin-4 (5H)-ones 5 were designed and synthesized. Some of these new heterocycles exhibited more potent bronchodilator activity in vitro and in vivo than theophylline. With respect to modification at the 5-position, both phenyl and n-butyl substitution produced potent activity. Though bulk tolerance at N-3 is observed with short ...

Related Articles:

Synthesis and biological evaluation of new 1, 2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity …

[Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088]

3-(1, 1-Dioxo-2 H-(1, 2, 4)-benzothiadiazin-3-yl)-4-hydroxy-2 (1 H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase

[Tedesco, Rosanna; Shaw, Antony N.; Bambal, Ramesh; Chai, Deping; Concha, Nestor O.; Darcy, Michael G.; Dhanak, Dashyant; Fitch, Duke M.; Gates, Adam; Gerhardt, Warren G.; Halegoua, Dina L.; Han, Chao; Hofmann, Glenn A.; Johnston, Victor K.; Kaura, Arun C.; Liu, Nannan; Keenan, Richard M.; Lin-Goerke, Juili; Sarisky, Robert T.; Wiggall, Kenneth J.; Zimmerman, Michael N.; Duffy, Kevin J. Journal of Medicinal Chemistry, 2006 , vol. 49, # 3 p. 971 - 983]

Quinazolineacetic acids and related analogs as aldose reductase inhibitors

[Malamas, Michael S.; Millen, Jane Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1492 - 1503]

More Articles...