Journal of medicinal chemistry

Quinazolineacetic acids and related analogs as aldose reductase inhibitors

MS Malamas, J Millen

Index: Malamas, Michael S.; Millen, Jane Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1492 - 1503

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Citation Number: 175

Abstract

A variety of 2, 4-dioxoquinazolineacetic acids (10, 11) were synthesized as hybrids of the known aldose reductase inhibitors alrestatin (a), ICI-105,552 (9), and ICI-128,436 (2) and evaluated for their ability to inhibit partially purified bovine lens aldose reductase (in vitro) and their effectiveness to decrease galactitol accumulation in the 4-day galactosemic rat model (in vivo). In support to SAR studies, related analogues pyrimidinediones (12), ...

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