New substituted 9-alkylpurines as adenosine receptor ligands

E Camaioni, S Costanzi, S Vittori, R Volpini…

Index: Camaioni, Emidio; Costanzi, Stefano; Vittori, Sauro; Volpini, Rosaria; Klotz, Karl-Norbert; Cristalli, Gloria Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 5 p. 523 - 533

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Citation Number: 94

Abstract

In the present study an investigation of the structure–activity relationships in 9-ethylpurine derivatives, aimed at preparing A1, A2A, A2B, and A3 selective adenosine receptor antagonists, was undertaken. Our synthetic approach was to introduce various substituents (amino, alkoxy and alkynyl groups) into the 2-, 6-, or 8-positions of the purine ring. The starting compounds for each series of derivatives were respectively: 2-iodo-9- ...