titanium isopropoxide as efficient catalyst for the Aza-Baylis-Hillman Reaction. selective formation of α-methylene-β-amino acid derivatives

D Balan, H Adolfsson

Index: Balan, Daniela; Adolfsson, Hans Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2329 - 2334

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Citation Number: 59

Abstract

The direct formation of α-methylene-β-amino acid derivatives is achieved using the aza version of the Baylis-Hillman protocol. The products are readily formed in a three-component one-pot reaction between arylaldehydes, sulfonamides, and α, β-unsaturated carbonyl compounds. The reaction is efficiently catalyzed by titanium isopropoxide and 2- hydroxyquinuclidine in the presence of molecular sieves. The protocol allows for structural ...