Process Development of Selectively Benzoylated and Fluorinated Glycosyl Donors

…, W Subotkowski, W Tomasik, BJ Vanasse…

Index: Weiberth, Franz J.; Gill, Harpal S.; Jiang, Ying; Lee, George E.; Lienard, Philippe; Pemberton, Clive; Powers, Matthew R.; Subotkowski, Witold; Tomasik, Witold; Vanasse, Benoit J.; Yu, Yong Organic Process Research and Development, 2010 , vol. 14, # 3 p. 623 - 631

Full Text: HTML

Citation Number: 6

Abstract

Sodium-glucose transporters (SGLT) are a family of proteins that have an important role in transporting glucose across cellular membranes against a concentration gradient. These proteins are predominantly expressed in intestinal mucosa (SGLT1) and kidney tubules (SGLT1 and SGLT2) where they mediate intestinal absorption and renal reabsorption of glucose.(1) SAR7226 (1) emerged as a promising SGLT1/SGLT2 inhibitor, potentially useful for the treatment of diabetes,(2) ...