Preparation of polycyclic azaarenes by an extended pomeranz-fritsch procedure

MJE Hewlins, R Salter

Index: Hewlins, Michael J. E.; Salter, Rhys Synthesis, 2007 , # 14 p. 2157 - 2163

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Citation Number: 6

Abstract

Abstract An extension of the Pomeranz-Fritsch procedure has been evaluated as a route to some polycyclic azaarenes. Aromatic aldehydes were treated with the dimethyl and diethyl acetals of 2-aminoethanal, the resulting imines reduced to amines which were tosylated and the resulting sulfonamides treated under a range of acidic conditions. The two naphthaldehydes led to benzo [f] isoquinoline and benzo [h] isoquinoline in overall yields ...