Tetrahedron Letters

Green iodination of pyrazoles with iodine/hydrogen peroxide in water

MM Kim, RT Ruck, D Zhao, MA Huffman

Index: Kim, Mary M.; Ruck, Rebecca T.; Zhao, Dalian; Huffman, Mark A. Tetrahedron Letters, 2008 , vol. 49, # 25 p. 4026 - 4028

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Citation Number: 48

Abstract

In this Letter, we describe a practical, green iodination of pyrazoles to form the corresponding 4-iodopyrazole derivatives. The reaction takes place in water, using only 0.5 equiv of iodine and 0.6 equiv of hydrogen peroxide, a system that generates water as the only reaction by-product.