Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

…, M Desjardins, D Soulet, R Charest-Gaudreault…

Index: Covassin, Laurence; Desjardins, Michel; Soulet, Denis; Charest-Gaudreault, Rene; Audette, Marie; Poulin, Richard Bioorganic and Medicinal Chemistry Letters, 2003 ,  vol. 13,  # 19  p. 3267 - 3271

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Citation Number: 13

Abstract

Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.