Facile and highly selective 5′-desilylation of multisilylated nucleosides

XF Zhu, HJ Williams, AI Scott

Index: Zhu, Xue-Feng; Williams, Howard J.; Ian Scott Journal of the Chemical Society, Perkin Transactions 1, 2000 ,  # 15  p. 2305 - 2306

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Citation Number: 11

Abstract

Since its introduction by Stork and Hudrlik, 1 and Corey and Venkateswarlu, 2 the tert- butyldimethylsilyl (TBDMS) group has become the most popular and useful hydroxy protecting group in chemical synthesis. 3, 4 One of the greatest challenges in this field is the selective deprotection of primary TBDMS groups in the presence of their secondary counterparts, a procedure which has considerable utility for synthetic chemists. 5 During a ...