Design and synthesis of calcium responsive magnetic resonance imaging agent: Its relaxation and luminescence studies

J Tanwar, A Datta, K Chauhan, SS Kumaran…

Index: Tanwar, Jyoti; Datta, Anupama; Chauhan, Kanchan; Kumaran, S. Senthil; Tiwari, Anjani K.; Kadiyala, K. Ganesh; Pal, Sunil; Thirumal; Mishra, Anil K. European Journal of Medicinal Chemistry, 2014 ,  vol. 82, p. 225 - 232

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Abstract

Abstract Calcium concentration modulation both inside and outside cell is of considerable interest for nervous system function in normal and pathological conditions. MRI has potential for very high spatial resolution at molecular/cellular level. Design, synthesis and evaluation of Gd-DO3A-AME-NPHE, a calcium responsive MRI contrast agent is presented. The probe is comprised of a Gd 3+-DO3A core coupled to iminoacetate coordinating groups for ...