Tetrahedron

A simple preparation of 5′-O-dimethoxytrityl deoxyribonucleoside 3′-O-phosphorbisdiethylamidites as useful intermediates in the synthesis of …

K Yamana, Y Nishijima, A Oka, H Nakano, O Sangen…

Index: Yamana, Kazushige; Nishijima, Yoshitaka; Oka, Atsushi; Nakano, Hidehiko; Sangen, Osamu; et al. Tetrahedron, 1989 , vol. 45, # 13 p. 4135 - 4140

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Citation Number: 16

Abstract

5′-O-Dimethoxytrityl deoxyribonucleoside 3′-O-phosphorbisdiethylamidites were prepared by the selective phosphitylation of 5′-O-dinethoxytrityl deoxyribonucleosides with tris (diethylamino) phosphine in the presence of amino and tetrazole as catalyst. The bisamidites activated by p-nitrophenyltetrazole can be coupled efficiently with 5′-hydroxyl group of nucleoside on a solid support. Oligodeoxyribonucleotides were obtained in high ...

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