Direct Coupling of Pyrroles with Carbonyl Compounds: Short Enantioselective Synthesis of (S)??Ketorolac

PS Baran, JM Richter, DW Lin

Index: Baran, Phil S.; Richter, Jeremy M.; Lin, David W. Angewandte Chemie - International Edition, 2005 ,  vol. 44,  # 4  p. 609 - 612

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Citation Number: 128

Abstract

Pyrroles and indoles are the foundation of innumerable medicines, natural products, and synthetic materials.[1] Alkylations, acylations, and transition-metal-mediated couplings are the staple reactions for intermolecular CÀC bond formation between these heterocycles and other organic substrates.[1–3] Typically, organometallic couplings require that one [3] or both entities are prefunctionalized (ie halogenation or any other disposable functionality).[ ...