Cathodic Cyclisation of N??(Oxoalkyl) pyridinium Salts− Formation of Tricyclic Indolizidine and Quinolizidine Derivatives in Aqueous Medium

J Heimann, HJ Schäfer, R Fröhlich…

Index: Heimann, Jens; Schaefer, Hans J.; Froehlich, Roland; Wibbeling, Birgit European Journal of Organic Chemistry, 2003 ,  # 15  p. 2919 - 2932

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Citation Number: 5

Abstract

Abstract The cathodic cyclisation of N-(oxoalkyl) pyridinium salts, derived from 4- methylpyridine and cyclic ketones, afforded functionalised tricyclic indolizidine and quinolizidine derivatives in high yields. Through systematic variation of the ring size of the ketone and the cyclised ring, a series of four cyclopenta-/cyclohexa [a] indolizidines and- quinolizidines was obtained. The cyclisation was also applied to the synthesis of a ...