Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei

…, C Cervellati, F Dallocchio, R Hardré, L Salmon…

Index: Pasti, Claudia; Rinaldi, Eliana; Cervellati, Carlo; Dallocchio, Franco; Hardre, Renaud; Salmon, Laurent; Hanau, Stefania Bioorganic and Medicinal Chemistry, 2003 ,  vol. 11,  # 7  p. 1207 - 1214

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Citation Number: 22

Abstract

Sugar derivatives mimicking compounds which take part in the catalysed reaction have been assayed as alternative substrates and/or competitive inhibitors of 6-phosphogluconate dehydrogenase from Trypanosoma brucei and sheep liver. Phosphonate analogues have been synthesised and the new compound 5-deoxy-5-phosphono-d-arabinonate shows good selectivity towards the parasite enzyme. A number of 4-carbon and 5-carbon ...