Synthesis

Direct and Efficient Synthesis of Pyrrole-3-carbaldehydes by Vilsmeier–Haack Formylation of Pyrroles with Sterically Crowded Amides

PV Ilyin, AS Pankova, MA Kuznetsov

Index: Ilyin, Petrv.; Pankova, Alenas.; Kuznetsov, Mikhail A. Synthesis, 2012 , vol. 44, # 9 p. 1353 - 1358

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Abstract

Abstract A simple and convenient synthetic method to prepare N-substituted pyrrole-3- carbaldehydes by Vilsmeier–Haack formylation of pyrroles using sterically crowded formamides was developed. The dependence of the formylation regioselectivity on steric features of substrates and reagents is discussed.

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