Chemical and Pharmaceutical Bulletin

Studies on Thiamine Analogs; Synthesis of 3-[(2, 4-Dioxo-1, 2, 3, 4-tetrahydro-5-pyrimidinyl) methyl]-4-methyl-5-(2-hydroxyethyl) thiazolium Nitrate.

S Yamada, K Achiwa

Index: Yamada,S.; Achiwa,K. Chemical and Pharmaceutical Bulletin, 1961 ,  vol. 9, p. 119 - 123            

Full Text: HTML

Citation Number: 1

Abstract

A new thiamine analog, 3-(2, 4-dioxo-1, 2, 3, 4-tetrahydro-5-pyrimidinyl) methyl-4-methyl-5- (2-hydroxyethyl) thiazolium nitrate (II) was synthesized from 5-cyanouracil (III). In the course of the reduction of (III), thymine was obtained besides the amine (IV). Further, a new method for obtaining (IV) was found.