Asymmetric synthesis of (R)-(-)-baclofen via asymmetric dihydroxylation

VV Thakur, AS Paraskar, A Sudalai

Index: Thakur; Paraskar; Sudalai Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 ,  vol. 46,  # 2  p. 326 - 330

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Citation Number: 2

Abstract

Abstract: A short and efficient asymmetric synthesis of (R)-(–)-baclofen, a selective GABAB agonist has been described with an overall yield of 14% and 85% ee. The Os-catalyzed Sharpless asymmetric dihydroxylation of⍺, β-unsaturated olefin constitutes the key step in introducing stereogenic centers into the molecule.