Total synthesis of optically active monocrotaline, a carcinogenic pyrrolizidine alkaloid having an 11-membered dilactone
H Niwa, O Okamoto, K Yamada
Index: Niwa, Haruki; Okamoto, Osamu; Yamada, Kiyoyuki Tetrahedron Letters, 1988 , vol. 29, # 40 p. 5139 - 5142
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Abstract
Abstract Monocrotaline (1), a representative of carcinogenic pyrrolizidine alkaloids with an 11-membered dilactone has been synthesized in optically active form by virtue of regioselective coupling of (+)-retronecine (2) and the protected necic acid 3, the latter being synthesized enantioselectively from the Full-size image (< 1 K)
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