Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors

…, VK Kaushik, M Stewart, PJ Tummino…

Index: Dales, Natalie A.; Gould, Alexandra E.; Brown, James A.; Calderwood, Emily F.; Guan, Bing; Minor, Charles A.; Gavin, James M.; Hales, Paul; Kaushik, Virendar K.; Stewart, Michael; Tummino, Peter J.; Vickers, Chad S.; Ocain, Timothy D.; Patane, Michael A. Journal of the American Chemical Society, 2002 ,  vol. 124,  # 40  p. 11852 - 11853

Full Text: HTML

Citation Number: 117

Abstract

Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. We implemented a rational design approach to identify potent and selective ACE2 inhibitors. To this end, picomolar inhibitors of ACE2 were designed and synthesized.