Synthesis

Further improvements of the synthesis of alkynes from aldehydes

GJ Roth, B Liepold, SG Müller, HJ Bestmann

Index: Roth, Gerald J.; Liepold, Bernd; Mueller, Stephan G.; Bestmann, Hans Juergen Synthesis, 2004 , # 1 p. 59 - 62

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Citation Number: 146

Abstract

Abstract A highly convenient way to perform the synthesis of alkynes from aldehydes is reported. The procedure utilizes a new in situ preparation of dimethyldiazomethylphosphonate. As a consequence a commercially available reagent can now be used, circumventing a disadvantage of earlier protocols. The easy one-pot procedure avoids the use of strong bases, low temperatures and inert gas techniques.

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