Organic letters

Chiral Silanes via Asymmetric Hydrosilylation with Catalytic CuH

BH Lipshutz, N Tanaka, BR Taft, CT Lee

Index: Lipshutz, Bruce H.; Tanaka, Naoki; Taft, Benjamin R.; Lee, Ching-Tien Organic Letters, 2006 ,  vol. 8,  # 10  p. 1963 - 1966

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Citation Number: 63

Abstract

CuH-catalyzed asymmetric conjugate reduction of β-silyl-α, β-unsaturated esters has been developed. Using PMHS as a stoichiometric source of hydride and in situ generated CuH ligated by Solvias' JOSIPHOS analogue PPF-P (t-Bu) 2 leads to highly enantioselective 1, 4- reductions.