Synthesis of nitrones using the methyltrioxorhenium/hydrogen peroxide system

…, K Iyanar, J Chen, JT Wearing

Index: Murray, Robert W.; Iyanar, Kaliappan; Chen, Jianxin; Wearing, James T. Journal of Organic Chemistry, 1996 ,  vol. 61,  # 23  p. 8099 - 8102

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Citation Number: 119

Abstract

Nitrones are important organic compounds because of their use in organic synthesis 1 and their use as spin traps. 2,3 The latter usage includes nitrones as scavengers of radicals in the biomedical area. A number of nitrone syntheses have been described. 1,4 Many of these methods involve the oxidation of hydroxylamines which generally are not readily accessible. We have reported 4a that the oxidation of secondary amines with dimethyldioxirane provides a convenient ...