Synthesis and preliminary cytotoxicity evaluation of new diarylamides and diarylureas possessing 2, 3-dihydropyrrolo [3, 2-b] quinoline scaffold

HJ Kim, MI El-Gamal, YS Lee…

Index: Kim, Hyun-Jin; El-Gamal, Mohammed I.; Lee, Yong Sup; Oh, Chang-Hyun Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 8 p. 2480 - 2486

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Citation Number: 5

Abstract

Abstract A new series of diarylamides and diarylureas having 2, 3-dihydropyrrolo [3, 2-b] quinoline scaffold was synthesized. Their in vitro antiproliferative activities were tested over NCI-60 cancer cell lines of nine different cancer types. Some target compounds showed good inhibition percentages over different cell lines. Among all the target compounds, compound 1f possessing 6, 7-dimethoxy-2, 3-dihydropyrrolo [3, 2-b] quinoline nucleus, ...

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