Journal of medicinal chemistry

Synthesis of spin traps specific for hydroxyl radical

GM Rosen, MJ Turner III

Index: Rosen, Gerald M.; Turner, Marvin J. Journal of Medicinal Chemistry, 1988 ,  vol. 31,  # 2  p. 428 - 432

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Citation Number: 49

Abstract

Two nitrones, 3, 3-diethyl-5, 5-dimethylpyrroline 1-oxide (DEDMPO) and 3, 3, 5, 5- tetramethylpyrroline 1-oxide (M, PO), were synthesized by the zinc/ammonium chloride reduction of appropriately substituted y-nitrocarbonyl compounds, followed by addition of methylmagnesium bromide to the resulting intermediate nitrones. The lipophilicities of these nitrones were estimated by determining their partition coefficients in an 1-octanol/water ...