Design and synthesis of fluoroacylshikonin as an anticancer agent

WY Kong, XF Chen, J Shi, SK Baloch, JL Qi, HL Zhu…

Index: Kong, Wen-Yao; Chen, Xiao-Feng; Shi, Jing; Baloch, Shahla Karim; Qi, Jin-Liang; Zhu, Hai-Liang; Wang, Xiao-Ming; Yang, Yong-Hua Chirality, 2013 , vol. 25, # 11 p. 757 - 762

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Citation Number: 6

Abstract

ABSTRACT A series of shikonin derivatives, selectively acylated by various fluorinated carboxylic acids at the side chain of shikonin, were synthesized and their anticancer activity evaluated, in which eight compounds are reported for the first time. Among all the compounds tested, compound S7 showed the most potent anticancer activity against B16- F10 (malignant melanoma cells), MG63 (human osteosarcoma cells), and A549 (lung ...