Antineoplastic agents. Part 189. The absolute configuration and synthesis of natural (-)-dolastatin 10

…, F Hogan, P Lloyd-Williams, DL Herald…

Index: Pettit; Singh; Hogan; Lloyd-Williams; Herald; Burkett; Clewlow Journal of the American Chemical Society, 1989 ,  vol. 111,  # 14  p. 5463 - 5465

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Citation Number: 170

Abstract

The fascinating sea hare Dolabella auricularia was known to certain ancient Greeks and Romans for various medical or nefarious2s3 purposes. As early as 200 BC the Greek Nicandros recommended extracts of this opisthobranch (Subclass, Mollusca phylum) for treatment of certain diseases.) Over the past 16 years we have vigorously pursued the powerful cytostatic and antineoplastic constituents of D. auricularia collected in the ...