Journal of medicinal chemistry

Interactions of thiol-containing androgens with human placental aromatase

PJ Bednarski, SD Nelson

Index: Bednarski, Patrick J.; Nelson, Sidney D. Journal of Medicinal Chemistry, 1989 ,  vol. 32,  # 1  p. 203 - 213

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Citation Number: 46

Abstract

A series of thiol androgens were synthesized and investigated to characterize structural features important for the inhibition of aromatase. Analogues of androstenedione with thiol groups in either the 2a-, lop-, or 19-positions caused time-dependent inhibition of human placental aromatase. When their KI and k,,, values were compared with those of 4- hydroxyandrost-4-ene-3, 17-dione (4-OHa) and 10/3-propargylestr-4-ene-3, 17-dione ( ...