Isothiazoles as active-site inhibitors of HCV NS5B polymerase

S Yan, T Appleby, E Gunic, JH Shim, T Tasu…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 1 p. 28 - 33

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Citation Number: 45

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... 3 Hence, there is an increasing demand for new anti-HCV therapies to fulfill this unmet medical need. ... 4 Medicinal chemistry pursuits of this polymerase for anti-HCV drug-discovery have led to the identification of numerous classes of ...