The CYP2B6* 6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro

…, MR Hutchinson, K Klein, UM Zanger, NJ Stanley…

Index: Li, Yibai; Coller, Janet K.; Hutchinson, Mark R.; Klein, Kathrin; Zanger, Ulrich M.; Stanley, Nathan J.; Abell, Andrew D.; Somogyi, Andrew A. Drug Metabolism and Disposition, 2013 , vol. 41, # 6 p. 1264 - 1272

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Citation Number: 13

Abstract

Abstract Ketamine is primarily metabolized to norketamine by hepatic CYP2B6 and CYP3A4- mediated N-demethylation. However, the relative contribution from each enzyme remains controversial. The CYP2B6* 6 allele is associated with reduced enzyme expression and activity that may lead to interindividual variability in ketamine metabolism. We examined the N-demethylation of individual ketamine enantiomers using human liver microsomes ( ...