A Novel Method for the Synthesis of Actarit

…, J Yang, X Yan, Y Pan, F Wu, J Zhang…

Index: Zhou, Li-Yi; Yang, Jun; Yan, Xi-Qing; Pan, Yan-Juan; Wu, Feng; Zhang, Jing; Yan, Fu-Lin; Lu, Guang-Zhou Asian Journal of Chemistry, 2012 , vol. 24, # 4 p. 1538 - 1540

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Abstract

Abstract The specific synthetic route to synthesize the actarit (4-acetyl-amino phenylacetic acid) by acylation was designed in which p-amino benzaldehyde (a) and nitromethane (b) was used as the raw materials, through Knoevenagel reaction. The selective reduction of potassium borohydride and p-amino phenylacetic acid to be oxidated under the acidic conditions. After optimization of the synthetic conditions, the yield of each step was more ...