Microwave-assisted aliphatic fluorine–chlorine exchange using triethylamine trihydrofluoride (TREAT-HF)

JM Kremsner, M Rack, C Pilger, CO Kappe

Index: Kremsner, Jennifer M.; Rack, Michael; Pilger, Christian; Oliver Kappe Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3665 - 3668

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Citation Number: 35

Abstract

Aliphatic fluorine–chlorine exchange reactions can be performed under microwave conditions using TREAT-HF as a mild and selective fluorination reagent. The highly polar TREAT-HF couples efficiently with microwave irradiation and reaction temperatures of 250° C can be reached within 30s. Under these conditions dichloromethyl-and trichloromethyl substrates can be converted into the corresponding fluoro analogs within 5min. In order to ...