Efficient synthesis of β'-amino-α, β-unsaturated ketones

I Abrunhosa-Thomas, A Plas…

Index: Abrunhosa-Thomas, Isabelle; Plas, Aurelie; Kandepedu, Nishanth; Chalard, Pierre; Troin, Yves Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 486 - 495

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Abstract

Abstract A general and simple procedure to access chiral β'-amino-α, β-enones, in seven steps, from an α, β unsaturated ester has been described. The use of a Horner–Wadsworth– Emmons reaction as a key step for generating the β'-amino-α, β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.

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