Chemical Communications

Iridium catalysed synthesis of piperazines from diols

LU Nordstrøm, R Madsen

Index: Nordstrom, Lars Ulrik; Madsen, Robert Chemical Communications, 2007 , # 47 p. 5034 - 5036

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Citation Number: 12

Abstract

The piperazine moiety is an important pharmacophore which is found in a large number of biologically active molecules. A recent survey of more than 1000 orally administered drugs showed that about 6% of these contained a piperazine fragment. 1 The synthesis of piperazines and substituted piperazines is usually performed by reduction of the corresponding (di)ketopiperazines 2,3 or by various cyclisation reactions, eg dialkylation of amines with bis(2-chloroethyl)amine 4 ...

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