Journal of fluorine chemistry

A new route to the synthesis of 5-fluorouracil

B Baasner, E Klauke

Index: Baasner, B.; Klauke, E. Journal of Fluorine Chemistry, 1989 , vol. 45, p. 417 - 430

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Citation Number: 10

Abstract

Abstract Starting from tetrafluoropyrimidine (1), selective fluorine/chlorine exchange reactions and selective hydrogenolysis of the chlorine substituents are described. Combination of these methods, together with a subsequent hydrolysis reaction, provides a new route to the synthesis of 5-fluorouracil via 4, 6-dichloro-2, 5-difluoropyrimidine and 4- chloro-2, 5-difluoropyrimidine.

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